Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
[HTML][HTML] The translational challenges of precision oncology
The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …
biological complexity and diversity of this disease. Technological advances in genomics …
Cohort profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Abstract Summary The Avon Longitudinal Study of Children and Parents (ALSPAC) was
established to understand how genetic and environmental characteristics influence health …
established to understand how genetic and environmental characteristics influence health …
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children …
Maternal smoking during pregnancy has been found to influence newborn DNA methylation
in genes involved in fundamental developmental processes. It is pertinent to understand the …
in genes involved in fundamental developmental processes. It is pertinent to understand the …
Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction
RE Wittenberg, SL Wolfman, M De Biasi, JA Dani - Neuropharmacology, 2020 - Elsevier
Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …
Causal inference in developmental origins of health and disease (DOHaD) research
SH Gage, MR Munafò… - Annual review of …, 2016 - annualreviews.org
Studies of the developmental origins of health and disease (DOHaD) often rely on
prospective observational data, from which associations between developmental exposures …
prospective observational data, from which associations between developmental exposures …
Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: Findings from Mendelian randomization and …
JS Brand, R Gaillard, J West, RRC McEachan… - PLoS …, 2019 - journals.plos.org
Background Maternal smoking during pregnancy is an established risk factor for low infant
birth weight, but evidence on critical exposure windows and timing of fetal growth restriction …
birth weight, but evidence on critical exposure windows and timing of fetal growth restriction …
[HTML][HTML] Mendelian randomization in health research: using appropriate genetic variants and avoiding biased estimates
Mendelian randomization methods, which use genetic variants as instrumental variables for
exposures of interest to overcome problems of confounding and reverse causality, are …
exposures of interest to overcome problems of confounding and reverse causality, are …
[HTML][HTML] Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium
Objectives To investigate whether associations of smoking with depression and anxiety are
likely to be causal, using a Mendelian randomisation approach. Design Mendelian …
likely to be causal, using a Mendelian randomisation approach. Design Mendelian …
[HTML][HTML] Using Mendelian randomization to determine causal effects of maternal pregnancy (intrauterine) exposures on offspring outcomes: Sources of bias and …
Mendelian randomization (MR), the use of genetic variants as instrumental variables (IVs) to
test causal effects, is increasingly used in aetiological epidemiology. Few of the …
test causal effects, is increasingly used in aetiological epidemiology. Few of the …