Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

Simple Summary Radiotherapy with carbon ions has been used for over 20 years in Asia
and Europe and is now planned in the USA. The physics advantages of carbon ions …

Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

With the emergence of individualized medicine and the increasing amount and complexity of
available medical data, a growing need exists for the development of clinical decision …

The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …

Over the last few years, cancer immunotherapy experienced tremendous developments and
it is nowadays considered a promising strategy against many types of cancer. However, the …

Hypoxia was identified as a microenvironmental component of solid tumours over 60 years
ago and was immediately recognised as a potential barrier to therapy through the reliance of …

Background Hypoxia is a well recognised parameter of tumour resistance to radiotherapy, a
number of anticancer drugs and potentially immunotherapy. In a previously published …

Purpose Several individual clinical and preclinical studies have shown the possibility of
evaluating tumor hypoxia by using noninvasive positron emission tomography (PET). The …

Solid tumours often present regions with severe oxygen deprivation (hypoxia), which are
resistant to both chemotherapy and radiotherapy. Increased radiosensitivity as a function of …