RNA viruses carry out selective packaging of their genomes in a variety of ways, many
involving a genomic packaging signal. The first coronavirus packaging signal was …

The signal recognition particle (SRP) and its receptor compose a universally conserved and
essential cellular machinery that couples the synthesis of nascent proteins to their proper …

The human immune system displays substantial variation between individuals, leading to
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …

Ribosomes translate genetic information encoded by messenger RNA into proteins. Many
aspects of translation and its regulation are specific to eukaryotes, whose ribosomes are …

Cryo-electron tomograms capture a wealth of structural information on the molecular
constituents of cells and tissues. We present DeePiCt (deep picker in context), an open …

Protein synthesis in all cells is carried out by macromolecular machines called ribosomes.
Although the structures of prokaryotic, yeast and protist ribosomes have been determined …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

This Meeting Review describes the proceedings and conclusions from the inaugural
meeting of the Electron Microscopy Validation Task Force organized by the Unified Data …

Eukaryotic ribosomes are substantially larger and more complex than their bacterial
counterparts. Although their core function is conserved, bacterial and eukaryotic protein …

Structures of the bacterial ribosome have provided a framework for understanding universal
mechanisms of protein synthesis. However, the eukaryotic ribosome is much larger than it is …