Gene maps, or annotations, enable us to navigate the functional landscape of our genome.
They are a resource upon which virtually all studies depend, from single-gene to genome …

High-throughput RNA sequencing (RNA-seq) promises a comprehensive picture of the
transcriptome, allowing for the complete annotation and quantification of all genes and their …

Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing
an ensemble of transcript isoforms that give rise to substantial diversity. Here we have …

Recent transcriptome studies have revealed that a large number of transcripts in mammals
and other organisms do not encode proteins but function as noncoding RNAs (ncRNAs) …

This study describes comprehensive polling of transcription start and termination sites and
analysis of previously unidentified full-length complementary DNAs derived from the mouse …

Antisense transcription (transcription from the opposite strand to a protein-coding or sense
strand) has been ascribed roles in gene regulation involving degradation of the …

Mammalian promoters can be separated into two classes, conserved TATA box–enriched
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG …

We introduce cap analysis gene expression (CAGE), which is based on preparation and
sequencing of concatamers of DNA tags deriving from the initial 20 nucleotides from 5′ end …

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The identification and characterization of mammalian core promoters and transcription start
sites is a prerequisite to understanding how RNA polymerase II transcription is controlled …