The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Covering: 2006 to 2017 Actinomycetes have been, for decades, one of the most important
sources for the discovery of new antibiotics with an important number of drugs and analogs …

Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

Covering: up to 2015 This review summarises the accumulated knowledge about
characterised bacterial terpene cyclases. The structures of identified products and of …

Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Covering: up to July 2023 Terpene cyclases (TCs) catalyze some of the most complicated
reactions in nature and are responsible for creating the skeletons of more than 95 000 …

Polycyclic diterpenes exhibit many important biological activities, but de novo synthetic
access to these molecules is highly challenging because of their structural complexity …

Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or
“orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases …

Covering: up to July 2019 Terpene synthases (TSs) are responsible for generating much of
the structural diversity found in the superfamily of terpenoid natural products. These elegant …

Covering: 2000 to 2019 Natural products (NPs) are important sources of human therapeutic
agents and pesticides. To prevent self-harm from bioactive NPs, some microbial producers …