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Regulation of carboxylesterases and its impact on pharmacokinetics and pharmacodynamics: an up-to-date review
ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
Association between CES1 rs2244613 and the pharmacokinetics and safety of dabigatran: Meta-analysis and quantitative trait loci analysis
Objective To date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on
the pharmacokinetics (PKs) and safety of dabigatran remains controversial. Hence, a …
the pharmacokinetics (PKs) and safety of dabigatran remains controversial. Hence, a …
Prediction of carboxylesterase 1-mediated in vivo drug interaction between methylphenidate and cannabinoids using static and physiologically based …
Y Qian, JS Markowitz - Drug Metabolism and Disposition, 2022 - Elsevier
The use of cannabis products has increased substantially. Cannabis products have been
perceived and investigated as potential treatments for attention-deficit/hyperactivity disorder …
perceived and investigated as potential treatments for attention-deficit/hyperactivity disorder …
[LIVRE][B] Enantiomeric pharmacokinetics of methylphenidate and processing speed measures in adults with ADHD and substance use disorders
M Arvidsson - 2024 - search.proquest.com
The overall aim of this thesis was to investigate the interindividual variability in the
enantioselective pharmacokinetics of methylphenidate (MPH) in healthy adults as well as in …
enantioselective pharmacokinetics of methylphenidate (MPH) in healthy adults as well as in …
LC‐MS/MS‐Based Proteomics Methods for Quantifying Drug‐Metabolizing Enzymes and Transporters
Quantification of drug‐metabolizing enzymes and transporters expressed in the human body
is a critical step to understand a drug's pharmacokinetics. Advancements in tandem mass …
is a critical step to understand a drug's pharmacokinetics. Advancements in tandem mass …
Laboratory and genetic markers for assessing liver function to predict drug metabolism and detect drug-induced liver injury
C Breukers - 2024 - studenttheses.uu.nl
Introduction: To date, liver function is measured with general liver function tests and requires
assessment prior treatment in vulnerable patient groups, as it influences drug metabolism …
assessment prior treatment in vulnerable patient groups, as it influences drug metabolism …
Pharmacometric Modeling and Simulation in Special Populations
J **ao - 2022 - deepblue.lib.umich.edu
Pharmacometrics modeling encompasses both pharmacokinetics (PK) and
pharmacodynamics (PD) data to quantitatively describe the dose-exposure-response …
pharmacodynamics (PD) data to quantitatively describe the dose-exposure-response …