Matrisomal components involved in regenerative wound healing in axolotl and Acomys: implications for biomaterial development

N Avila-Martinez, M Gansevoort, J Verbakel… - Biomaterials …, 2023 - pubs.rsc.org
Achieving regeneration in humans has been a long-standing goal of many researchers.
Whereas amphibians like the axolotl (Ambystoma mexicanum) are capable of regenerating …

Integrative Analysis of Motor Neuron and Microglial Transcriptomes from SOD1G93A Mice Models Uncover Potential Drug Treatments for ALS

E Kubat Oktem, B Aydin, M Yazar, KY Arga - Journal of Molecular …, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neurons that mainly affects the
motor cortex, brainstem, and spinal cord. Under disease conditions, microglia could possess …

Three candidate anticancer drugs were repositioned by integrative analysis of the transcriptomes of species with different regenerative abilities after injury

EK Oktem, U Demir, M Yazar, KY Arga - Computational Biology and …, 2023 - Elsevier
Regeneration is a homeostatic process that involves the restoration of cells and body parts.
Most of the molecular mechanisms and signalling pathways involved in wound healing …

Preclinical Molecular Signatures of Spinal Cord Functional Restoration: Optimizing the Metamorphic Axolotl (Ambystoma mexicanum) Model in Regenerative …

T Demircan, H Hacıbektaşoğlu, M Sibai… - OMICS: A Journal of …, 2020 - liebertpub.com
Regenerative medicine offers hope for patients with diseases of the central and peripheral
nervous system. Urodele amphibians such as axolotl display an exceptional regenerative …

Drug Repositioning Identifies Six Drug Candidates for Systemic Autoimmune Diseases by Integrative Analyses of Transcriptomes from Scleroderma, Systemic Lupus …

EK Oktem, M Yazar - OMICS: A Journal of Integrative Biology, 2022 - liebertpub.com
The mechanisms of systemic autoimmune diseases (ADs) are still not clearly understood.
Understanding the etiology of systemic ADs and identifying new therapeutic targets require …

Travma Sonrası Stres Bozukluğu (TSSB) Tedavisine Yönelik Moleküler Hedefler ve Yeniden Konumlandırılan İlaçlar

EK Oktem - Afyon Kocatepe Üniversitesi Fen Ve Mühendislik … - dergipark.org.tr
Travma sonrası stres bozukluğu (TSSB), fiziksel hasar veya kaygı gibi zihinsel şok içeren bir
kazayı takiben görülen travmanın neden olduğu zihinsel bir hastalıktır. Toplumda yaygın …

Travma sonrası stres bozukluğu (TSSB) tedavisine yönelik moleküler hedefler ve yeniden konumlandırılan ilaçlar

E Kubat Öktem - 2023 - acikerisim.aku.edu.tr
Travma sonrası stres bozukluğu (TSSB), fiziksel hasar veya kaygı gibi zihinsel şok içeren bir
kazayı takiben görülen travmanın neden olduğu zihinsel bir hastalıktır. Toplumda yaygın …