The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

Islet amyloid polypeptide (IAPP), a putative polypeptide hormone, is a product of pancreatic
beta-cells and the major constituent of the amyloid deposits seen mainly in islets of type 2 …

Islet amyloid polypeptide (IAPP) has been identified as the major constituent of the
pancreatic amyloid of non-insulin-dependent diabetes mellitus (NIDDM) and is also present …

I. Introduction T HE calcitonin (CT) and calcitonin gene-related peptide (CGRP) are derived
from the CT/CGRP gene, which is localized in chromosome 11. Alternative splicing of the …

Islet amyloid polypeptide (IAPP, amylin) is secreted from pancreatic islet β-cells and
converted to amyloid deposits in type 2 diabetes. Conversion from soluble monomer, IAPP 1 …

The islet in type 2 diabetes is characterized by a deficit in β-cell mass, increased β-cell
apoptosis, and impaired insulin secretion. Also, islets in type 2 diabetes often contain …

Pancreatic islet amyloid deposits are a characteristic pathologic feature of non-insulin-
dependent diabetes mellitus and contain islet amyloid polypeptide (IAPP; amylin). We used …

Human islet amyloid polypeptide (hIAPP) accumulates as pancreatic amyloid in type 2
diabetes and readily forms fibrils in vitro. Investigations into the mechanism of hIAPP fibril …

As the population is aging, the incidence of age-related neurodegenerative diseases, such
as Alzheimer and Parkinson disease, is growing. The pathology of neurodegenerative …