Microglia and monocytes/macrophages polarization reveal novel therapeutic mechanism against stroke

M Kanazawa, I Ninomiya, M Hatakeyama… - International journal of …, 2017 - mdpi.com
Stroke is a leading cause of morbidity and mortality worldwide, and consists of two types,
ischemic and hemorrhagic. Currently, there is no effective treatment to increase the survival …

[HTML][HTML] Clinical trials of stem cell therapy for cerebral ischemic stroke

M Kawabori, H Shichinohe, S Kuroda… - International Journal of …, 2020 - mdpi.com
Despite recent developments in innovative treatment strategies, stroke remains one of the
leading causes of death and disability worldwide. Stem cell therapy is currently attracting …

Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles

S Dabrowska, A Andrzejewska, B Lukomska… - Journal of …, 2019 - Springer
Ischemic stroke is the third cause of death in the developed countries and the main reason
of severe disability. Brain ischemia leads to the production of damage-associated molecular …

Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments

PM George, GK Steinberg - Neuron, 2015 - cell.com
Stroke remains a leading cause of death and disability in the world. Over the past few
decades our understanding of the pathophysiology of stroke has increased, but greater …

[BOK][B] Broken movement: the neurobiology of motor recovery after stroke

JW Krakauer, ST Carmichael - 2022 - books.google.com
An account of the neurobiology of motor recovery in the arm and hand after stroke by two
experts in the field. Stroke is a leading cause of disability in adults and recovery is often …

Enhancing brain plasticity to promote stroke recovery

F Su, W Xu - Frontiers in neurology, 2020 - frontiersin.org
Stroke disturbs both the structural and functional integrity of the brain. The understanding of
stroke pathophysiology has improved greatly in the past several decades. However …

Stem cell transplantation therapy and neurological disorders: current status and future perspectives

MM Rahman, MR Islam, MT Islam, M Harun-Or-Rashid… - Biology, 2022 - mdpi.com
Simple Summary This review highlights the scope of available treatment options for
neurological diseases, especially stem cell transplantation therapy, which provides new …

A phase 2 randomized, sham-controlled trial of internal carotid artery infusion of autologous bone marrow–derived ALD-401 cells in patients with recent stable …

SI Savitz, D Yavagal, G Rappard, W Likosky… - Circulation, 2019 - ahajournals.org
Background: Ischemic stroke has no approved treatments to enhance recovery. ALD-401 is
an enriched population of aldehyde dehydrogenase-bright stem cells, capable of reducing …

Adult stem cells for regenerative therapy

N Gurusamy, A Alsayari, S Rajasingh… - Progress in molecular …, 2018 - Elsevier
Cell therapy has been identified as an effective method to regenerate damaged tissue. Adult
stem cells, also known as somatic stem cells or resident stem cells, are a rare population of …

Intra-arterial bone marrow mononuclear cells in ischemic stroke: a pilot clinical trial

F Moniche, A Gonzalez, JR Gonzalez-Marcos… - Stroke, 2012 - ahajournals.org
Background and Purpose—Bone marrow mononuclear cell (BM-MNC) intra-arterial
transplantation improves recovery in experimental models of ischemic stroke. We aimed to …