Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders
SB Nelson, V Valakh - Neuron, 2015 - cell.com
Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition …
mutations in many genes affecting the ratio between neuronal excitation and inhibition …
Neurotrophin signalling: novel insights into mechanisms and pathophysiology
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …
of neuronal survival, growth and differentiation during development. While trophic factors are …
[HTML][HTML] Retrovirus-like Gag protein Arc1 binds RNA and traffics across synaptic boutons
Summary Arc/Arg3. 1 is required for synaptic plasticity and cognition, and mutations in this
gene are linked to autism and schizophrenia. Arc bears a domain resembling retroviral …
gene are linked to autism and schizophrenia. Arc bears a domain resembling retroviral …
Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease
Though discovered over 100 years ago, the molecular foundation of sporadic Alzheimer's
disease (AD) remains elusive. To better characterize the complex nature of AD, we …
disease (AD) remains elusive. To better characterize the complex nature of AD, we …
TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K/Akt/Nrf2/Ferritin H pathway
Y Cheng, Y Gao, J Li, T Rui, Q Li, H Chen, B Jia… - Free Radical Biology …, 2023 - Elsevier
Ferroptosis is a form of regulated cell death that is mainly triggered by iron-dependent lipid
peroxidation. A growing body of evidence suggests that ferroptosis is involved in the …
peroxidation. A growing body of evidence suggests that ferroptosis is involved in the …
Neuron-derived estrogen regulates synaptic plasticity and memory
17β-estradiol (E2) is produced from androgens via the action of the enzyme aromatase. E2
is known to be made in neurons in the brain, but its precise functions in the brain are …
is known to be made in neurons in the brain, but its precise functions in the brain are …
BDNF mechanisms in late LTP formation: a synthesis and breakdown
Unraveling the molecular mechanisms governing long-term synaptic plasticity is a key to
understanding how the brain stores information in neural circuits and adapts to a changing …
understanding how the brain stores information in neural circuits and adapts to a changing …
NeuroMatic: an integrated open-source software toolkit for acquisition, analysis and simulation of electrophysiological data
Acquisition, analysis and simulation of electrophysiological properties of the nervous system
require multiple software packages. This makes it difficult to conserve experimental …
require multiple software packages. This makes it difficult to conserve experimental …
Intellectual disability and autism spectrum disorders: causal genes and molecular mechanisms
AK Srivastava, CE Schwartz - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common
developmental disorders present in humans. Combined, they affect between 3 and 5% of …
developmental disorders present in humans. Combined, they affect between 3 and 5% of …
[HTML][HTML] Arc protein: a flexible hub for synaptic plasticity and cognition
Mammalian excitatory synapses express diverse types of synaptic plasticity. A major
challenge in neuroscience is to understand how a neuron utilizes different types of plasticity …
challenge in neuroscience is to understand how a neuron utilizes different types of plasticity …