Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected
insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory …

Although human epidemiological and genetic studies are essential to elucidate the
aetiology of normal and aberrant ocular development, animal models have provided us with …

Recent studies have revealed unexpected connections between the mammalian Hedgehog
(Hh) signal transduction pathway and the primary cilium, a microtubule-based organelle that …

Over the past 20 years, the zebrafish has emerged as a powerful model organism for
studying cardiac development. Its ability to survive without an active circulation and …

The asymmetric polarization of cells allows specialized functions to be performed at discrete
subcellular locales. Spatiotemporal coordination of polarization between groups of cells …

Usher syndrome is the most common form of deaf-blindness. The syndrome is both clinically
and genetically heterogeneous, and to date, eight causative genes have been identified …

The formation and function of cilia involves the movement of intraflagellar transport (IFT)
particles underneath the ciliary membrane, along axonemal microtubules,. Although this …

Primary cilia are microtubule‐based, hair‐like sensory organelles present on the surface of
most growth‐arrested cells in our body. Recent research has demonstrated a crucial role for …

The centriole is the core structure of centrosome and cilium. Failure to restrict centriole
duplication to once per cell cycle has serious consequences and is commonly observed in …

Although lumen generation has been extensively studied through so-called cyst-formation
assays in Madin-Darby canine kidney (MDCK) cells, an underlying mechanism that leads to …