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Pathogenesis of allergic diseases and implications for therapeutic interventions
J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …
Decoding Toll-like receptors: Recent insights and perspectives in innate immunity
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …
system and are the first line of host defense against microbial pathogens by recognizing …
A second-generation M1-polarized CAR macrophage with antitumor efficacy
A Lei, H Yu, S Lu, H Lu, X Ding, T Tan, H Zhang… - Nature …, 2024 - nature.com
Chimeric antigen receptor (CAR) T cell therapies have successfully treated hematological
malignancies. Macrophages have also gained attention as an immunotherapy owing to their …
malignancies. Macrophages have also gained attention as an immunotherapy owing to their …
Toll-like receptor signaling and its role in cell-mediated immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
Inflammasomes are important sentinels of innate immune defence, sensing pathogens and
inducing cell death in infected cells. There are several inflammasome sensors that each …
inducing cell death in infected cells. There are several inflammasome sensors that each …
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
The innate immune response is critical for recognizing and controlling infections through the
release of cytokines and chemokines. However, severe pathology during some infections …
release of cytokines and chemokines. However, severe pathology during some infections …
Major pathways involved in macrophage polarization in cancer
Macrophages play an important role in tissue homeostasis, tissue remodeling, immune
response, and progression of cancer. Consequently, macrophages exhibit significant …
response, and progression of cancer. Consequently, macrophages exhibit significant …
Pattern recognition receptors in health and diseases
D Li, M Wu - Signal transduction and targeted therapy, 2021 - nature.com
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
A Ciesielska, M Matyjek, K Kwiatkowska - Cellular and molecular life …, 2021 - Springer
Abstract Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …
NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress
Innate immunity provides the first line of defense through multiple mechanisms, including
pyrogen production and cell death. While elevated body temperature during infection is …
pyrogen production and cell death. While elevated body temperature during infection is …