How can machine learning and multiscale modeling benefit ocular drug development?
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …
drug delivery space, distinctive barriers, and complicated biomechanical processes …
[HTML][HTML] Tear film–oriented diagnosis and tear film–oriented therapy for dry eye based on tear film dynamics
N Yokoi, GA Georgiev - Investigative Ophthalmology & Visual …, 2018 - tvst.arvojournals.org
Abstract In December 2010 and January 2012, 3% diquafosol sodium ophthalmic solution
and 2% rebamipide ophthalmic suspension, respectively, appeared first in Japan as …
and 2% rebamipide ophthalmic suspension, respectively, appeared first in Japan as …
Classification of fluorescein breakup patterns: a novel method of differential diagnosis for dry eye
N Yokoi, GA Georgiev, H Kato, A Komuro… - American journal of …, 2017 - Elsevier
Purpose To investigate the relationship between fluorescein breakup patterns (FBUPs) and
clinical manifestations in dry eye cases. Design Cross-sectional study. Methods In 106 eyes …
clinical manifestations in dry eye cases. Design Cross-sectional study. Methods In 106 eyes …
Dynamics of the tear film
RJ Braun - Annual Review of Fluid Mechanics, 2012 - annualreviews.org
This review discusses the current understanding of tear-film physiology and mathematical
models for some of its dynamics. First, a brief introduction to the tear film and the ocular …
models for some of its dynamics. First, a brief introduction to the tear film and the ocular …
Dynamics and function of the tear film in relation to the blink cycle
Great strides have recently been made in quantitative measurements of tear film thickness
and thinning, mathematical modeling thereof and linking these to sensory perception. This …
and thinning, mathematical modeling thereof and linking these to sensory perception. This …
[LIBRO][B] Interfacial convection in multilayer systems
A Nepomnyashchy, JC Legros, I Simanovskii - 2006 - Springer
The interfacial convection in multilayer systems is a widespread phenomenon that is of great
importance in numerous branches of technology, including chemical engineering, space …
importance in numerous branches of technology, including chemical engineering, space …
Contribution of mucins towards the physical properties of the tear film: a modern update
GA Georgiev, P Eftimov, N Yokoi - International journal of molecular …, 2019 - mdpi.com
Instability of the tear film (TF) protecting the ocular surface results in dry eye syndrome
(DES), the most prevalent public health ophthalmic disease affecting the quality of life of 10 …
(DES), the most prevalent public health ophthalmic disease affecting the quality of life of 10 …
Tear-film-oriented diagnosis for dry eye
N Yokoi, GA Georgiev - Japanese Journal of Ophthalmology, 2019 - Springer
Tear-film (TF) stability protects the ocular surface epithelium from desiccation and is ensured
via cooperation between the ocular surface components including constituents of the TF and …
via cooperation between the ocular surface components including constituents of the TF and …
Elastohydrodynamics of the eyelid wiper
MB Jones, GR Fulford, CP Please… - Bulletin of mathematical …, 2008 - Springer
This paper presents an elastohydrodynamic model of the human eyelid wiper. Standard
lubrication theory is applied to the fluid layer between the eyelid wiper and ocular surface …
lubrication theory is applied to the fluid layer between the eyelid wiper and ocular surface …
Mechanisms, imaging and structure of tear film breakup
Tear film breakup (BU) is an important aspect of dry eye disease, as a cause of ocular
aberrations, irritation and ocular surface inflammation and disorder. Additionally …
aberrations, irritation and ocular surface inflammation and disorder. Additionally …