Background—Pulmonary arterial hypertension (PAH) is characterized, in part, by decreased
endothelial nitric oxide (NO·) production and elevated levels of endothelin-1. Endothelin-1 is …

Two nuclear ER subtypes, ERα and ERβ, have been identified and cloned in 198644–46
and 1996, 47, 48 respectively. Notwithstanding their relatively low (59%) sequence identity …

Background T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif
(ITIM) domain (TIGIT) and programmed cell death protein 1 (PD-1) are important inhibitory …

To explore the expression pattern of the TRIB1 gene in yak follicles and its effect on the
steroidogenesis of granulosa cells (GCs). Here, 4–5 years old female yaks were treated as …

Adriamycin (ADR)-induced nephropathy in animals is an experimental analog of human
focal segmental glomerulosclerosis, which presents as severe podocyte injury and massive …

The cytochrome 11B2 aldosterone synthase gene (CYP11B2) one of the possible encoding
genes that relates to changes of aldosterone and blood pressure regulation. The aim is to …

As a fundamental regulator of mitochondrial function, peroxisome proliferator-activated
receptor gamma coactivator 1 alpha (PPARGC1A) acts as a powerful coactivator of many …

The kidney has a high energy demand and is dependent on oxidative metabolism for ATP
production. Accordingly, the kidney is rich in mitochondria, and mitochondrial dysfunction is …

Context: Endometriosis is an estrogen-dependent disease, and estrogen is overproduced by
abnormally elevated aromatase in endometriotic tissues. Peroxisome proliferator-activated …

The preovulatory hormonal surge (PS) consists of elevated circulating luteinizing hormone
(LH) and progesterone levels and serves as the primary trigger for ovarian follicle ovulation …