Automated model building and protein identification in cryo-EM maps
Interpreting electron cryo-microscopy (cryo-EM) maps with atomic models requires high
levels of expertise and labour-intensive manual intervention in three-dimensional computer …
levels of expertise and labour-intensive manual intervention in three-dimensional computer …
[HTML][HTML] Single particle cryo-EM map and model validation: It's not crystal clear
GC Lander - Current Opinion in Structural Biology, 2024 - Elsevier
Highlights•Single particle cryo-EM structure validation is an area of much-needed
development, and has seen significant recent advances.•The reported resolution of a single …
development, and has seen significant recent advances.•The reported resolution of a single …
Integrating model simulation tools and cryo‐electron microscopy
The power of computer simulations, including machine‐learning, has become an
inseparable part of scientific analysis of biological data. This has significantly impacted the …
inseparable part of scientific analysis of biological data. This has significantly impacted the …
Residue-level error detection in cryoelectron microscopy models
G Reggiano, W Lugmayr, D Farrell, TC Marlovits… - Structure, 2023 - cell.com
Building accurate protein models into moderate resolution (3–5 Å) cryoelectron microscopy
(cryo-EM) maps is challenging and error prone. We have developed MEDIC (Model Error …
(cryo-EM) maps is challenging and error prone. We have developed MEDIC (Model Error …
What do we know about the function of SARS-CoV-2 proteins?
The COVID-19 pandemic has highlighted the importance in the understanding of the biology
of SARS-CoV-2. After more than two years since the first report of COVID-19, it remains …
of SARS-CoV-2. After more than two years since the first report of COVID-19, it remains …
Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants
The evolution of SARS-CoV-2 variants with increased fitness has been accompanied by
structural changes in the spike (S) proteins, which are the major target for the adaptive …
structural changes in the spike (S) proteins, which are the major target for the adaptive …
The impact of AlphaFold2 on experimental structure solution
AlphaFold2 is a machine-learning based program that predicts a protein structure based on
the amino acid sequence. In this article, we report on the current usages of this new tool and …
the amino acid sequence. In this article, we report on the current usages of this new tool and …
[PDF][PDF] Errors in structural biology are not the exception
Y Gao, V Thorn, A Thorn - Acta Crystallographica Section D …, 2023 - journals.iucr.org
During the COVID-19 pandemic, the structural biology community swung into action quickly
and efficiently, and many urgent questions were solved by macromolecular structure …
and efficiently, and many urgent questions were solved by macromolecular structure …
Improving SARS-CoV-2 structures: Peer review by early coordinate release
This work builds upon the record-breaking speed and generous immediate release of new
experimental three-dimensional structures of the severe acute respiratory syndrome …
experimental three-dimensional structures of the severe acute respiratory syndrome …
[HTML][HTML] Predicted pH-dependent stability of SARS-CoV-2 spike protein trimer from interfacial acidic groups
VR Lobo, J Warwicker - Computational and structural biotechnology journal, 2021 - Elsevier
Transition between receptor binding domain (RBD) up and down forms of the SARS-CoV-2
spike protein trimer is coupled to receptor binding and is one route by which variants can …
spike protein trimer is coupled to receptor binding and is one route by which variants can …