Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal
homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress …

MTs are small cysteine-rich metal-binding proteins found in many species and, although
there are differences between them, it is of note that they have a great deal of sequence and …

The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of
endogenous and exogenous origin. Oxidative stress affects all structures of the human eye …

The functional human metallothionein (MT) genes are located on chromosome 16q13. We
have physically mapped the functional human MT locus by isolation and restriction digest …

Many, but not all, zinc-containing neurons in the brain are a subclass of the glutamatergic
neurons, and they are found predominantly in the telencephalon. These neurons store zinc …

In previous studies, we discovered a growth inhibitory factor (GIF) that was abundant in
normal human brain, but greatly reduced in Alzheimer's disease (AD) brain. Molecular …

Metallothionein (MT) genes encode small proteins that chelate metal ions through metal-
thiolate bonds with cysteine residues. MTs may have a role in cellular zinc homeostasis and …

Metallothionein (MT) was reported to be a potential negative regulator of apoptosis, and
various reports have suggested that it may play roles in carcinogenesis and drug resistance …

Initial verification of the essentiality of copper as a nutrient occurred over 60 years ago in
reports showing that the abnormal development of rats fed synthetic diets was reversed by …

The organization of the metallothionein (MT) gene family has been demonstrated to be
much more complex in humans than in the mouse, and possibly rodents in general. For …