Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review

FF Tuon, LR Dantas, PH Suss, VS Tasca Ribeiro - Pathogens, 2022 - mdpi.com
Pseudomonas aeruginosa is associated with several human infections, mainly related to
healthcare services. In the hospital, it is associated with resistance to several antibiotics …

Pseudomonas aeruginosa Biofilms: Host Response and Clinical Implications in Lung Infections

NM Maurice, B Bedi, RT Sadikot - American journal of respiratory …, 2018 - atsjournals.org
Pseudomonas aeruginosa is a major health challenge that causes recalcitrant multidrug-
resistant infections, especially in immunocompromised and hospitalized patients. P …

PPAR gamma: from definition to molecular targets and therapy of lung diseases

MV Carvalho, CF Gonçalves-de-Albuquerque… - International Journal of …, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor
superfamily that regulate the expression of genes related to lipid and glucose metabolism …

Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity

G Coquant, JP Grill, P Seksik - Frontiers in Immunology, 2020 - frontiersin.org
Among numerous molecules found in the gut ecosystem, quorum sensing (QS) molecules
represent an overlooked part that warrants highlighting. QS relies on the release of small …

Macrophages exposed to HIV viral protein disrupt lung epithelial cell integrity and mitochondrial bioenergetics via exosomal microRNA shuttling

Z Yuan, JR Petree, FEH Lee, X Fan, K Salaita… - Cell death & …, 2019 - nature.com
Antiretroviral therapy extends survival but does not eliminate HIV from its cellular reservoirs.
Between immune and stromal cells in the tissue microenvironment, a dynamic intercellular …

The interplay between the unfolded protein response, inflammation and infection in cystic fibrosis

P Trouvé, C Férec, E Génin - Cells, 2021 - mdpi.com
In cystic fibrosis (CF), p. Phe508del is the most frequent mutation in the Cystic Fibrosis
Transmembrane conductance Regulator (CFTR) gene. The p. Phe508del-CFTR protein is …

Small RNA-big impact: exosomal miRNAs in mitochondrial dysfunction in various diseases

X Li, Y Han, Y Meng, L Yin - RNA biology, 2024 - Taylor & Francis
Mitochondria are multitasking organelles involved in maintaining the cell homoeostasis.
Beyond its well-established role in cellular bioenergetics, mitochondria also function as …

Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction

NM Maurice, B Bedi, Z Yuan, JB Goldberg, M Koval… - Scientific reports, 2019 - nature.com
The pathogenicity of P. aeruginosa is dependent on quorum sensing (QS), an inter-bacterial
communication system that can also modulate host biology. The innate immune function of …

Peroxisome proliferator-activated receptor gamma activation promotes intestinal barrier function by improving mucus and tight junctions in a mouse colitis model

J Zhao, R Zhao, L Cheng, J Yang, L Zhu - Digestive and Liver Disease, 2018 - Elsevier
Background and aims Defects in mucus and intestinal epithelia can lead to intestinal
inflammation in colitis. Reduced peroxisome proliferator-activated receptor gamma (PPAR γ) …

Proteomic analysis of liver tissue reveals Aeromonas hydrophila infection mediated modulation of host metabolic pathways in Labeo rohita

MU Nissa, N Pinto, B Ghosh, U Singh, M Goswami… - Journal of …, 2023 - Elsevier
Aeromonas hydrophila (Ah) is a Gram-negative bacterium and a serious global pathogen
causing Motile Aeromonas Septicaemia (MAS) in fish leading to global loss in aquaculture …