Morphological observations have driven the course of biology ever since the first
microscope was built in the late sixteenth century. Molecular imaging is a rapidly emerging …

The development of miniaturized imaging equipment and reporter probes has improved our
ability to study animal models of disease, such as transgenic and knockout mice. These …

Current methods for programmed RNA editing using endogenous ADAR enzymes and
engineered ADAR-recruiting RNAs (arRNAs) suffer from low efficiency and bystander off …

Current tools for targeted RNA editing rely on the delivery of exogenous proteins or
chemically modified guide RNAs, which may lead to aberrant effector activity, delivery …

Tumour responses to treatment are still largely assessed from imaging measurements of
reductions in tumour size. However, this can take several weeks to become manifest and in …

The role of p53 as a central mediator of the DNA damage and other cellular stress
responses is well established. The ultimate growth-suppressive function of p53 in part …

Two genetic reporter systems were developed for multimodality reporter gene imaging of
different molecular-genetic processes using fluorescence, bioluminescence (BLI), and …

The aim of this study was to assess the efficacy human mesenchymal stem cells (hMSC) for
targeting microscopic tumors and suicide gene or cytokine gene therapy. Immunodeficient …

Molecular imaging includes proteomic, metabolic, cellular biologic process, and genetic
imaging. In a narrow sense, molecular imaging means genetic imaging and can be called …

The efficacy of 3 radiolabeled probes of current interest for imaging herpes simplex virus
type 1 thymidine kinase (HSV1-tk) expression in vivo with PET, including 124I-or 131I …