A global view of the human post-translational modification landscape
Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass …
metabolism and gene expression and maintain homeostasis. Advances in mass …
The chemical language of protein glycation
MS Martin, JW Jacob-Dolan, VTT Pham… - Nature Chemical …, 2024 - nature.com
Glycation is a non-enzymatic post-translational modification (PTM) that is correlated with
many diseases, including diabetes, cancer and age-related disorders. Although recent work …
many diseases, including diabetes, cancer and age-related disorders. Although recent work …
Reconsidering the role of protein glycation in disease
Protein glycation has long-been considered a toxic consequence of carbohydrate
metabolism. Yet recent evidence demonstrates tight regulation for these non-enzymatic post …
metabolism. Yet recent evidence demonstrates tight regulation for these non-enzymatic post …
Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin
Histone monoaminylation (ie., serotonylation and dopaminylation) is an emerging category
of epigenetic mark occurring on the fifth glutamine (Q5) residue of H3 N-terminal tail, which …
of epigenetic mark occurring on the fifth glutamine (Q5) residue of H3 N-terminal tail, which …
Chromatin structure in cancer
In the past decade, we have seen the emergence of sequence-based methods to
understand chromosome organization. With the confluence of in situ approaches to capture …
understand chromosome organization. With the confluence of in situ approaches to capture …
Non-enzymatic covalent modifications as a new chapter in the histone code
The interior of the cell abounds with reactive species that can accumulate as non-enzymatic
covalent modifications (NECMs) on biological macromolecules. These adducts interfere with …
covalent modifications (NECMs) on biological macromolecules. These adducts interfere with …
Effect of non-enzymatic glycosylation in the epigenetics of cancer
The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or
glycation of cellular proteins result in the generation and accumulation of advanced …
glycation of cellular proteins result in the generation and accumulation of advanced …
[HTML][HTML] Chemical proteomics approaches for protein post-translational modification studies
The diversity and dynamics of proteins play essential roles in maintaining the basic
constructions and functions of cells. The abundance of functional proteins is regulated by the …
constructions and functions of cells. The abundance of functional proteins is regulated by the …
Leveraging histone glycation for cancer diagnostics and therapeutics
Cancer cells undergo metabolic reprogramming to rely mostly on aerobic glycolysis (the
Warburg effect). The increased glycolytic intake enhances the intracellular levels of reactive …
Warburg effect). The increased glycolytic intake enhances the intracellular levels of reactive …
Epigenetic meets metabolism: novel vulnerabilities to fight cancer
Histones undergo a plethora of post-translational modifications (PTMs) that regulate
nucleosome and chromatin dynamics and thus dictate cell fate. Several evidences suggest …
nucleosome and chromatin dynamics and thus dictate cell fate. Several evidences suggest …