Single cells in genetically homogeneous microbial cultures exhibit marked phenotypic
individuality, a biological phenomenon that is considered to bolster the fitness of …

Genetically identical cells grown in the same culture display striking cell-to-cell
heterogeneity in gene expression and other traits. A crucial challenge is to understand how …

Phenotypic heterogeneity describes the variation that exists between individual cells, spores
or other biological entities within genetically-uniform populations of fungi or other organisms …

Delineating the strategies by which cells contend with combinatorial changing environments
is crucial for understanding cellular regulatory organization. When presented with two …

Upon homozygosis from a/α to a/a or α/α, Candida albicans must still switch from the
'white'to 'opaque'phenotype to mate. It was, therefore, surprising to discover that pheromone …

The study of regulatory networks in human pathogens such as Cryptococcus neoformans
provides insights into host-pathogen interactions that may allow for correlation of gene …

Candida glabrata is an opportunistic human pathogen that is increasingly associated with
candidemia, owing in part to the intrinsic and acquired high tolerance the organism exhibits …

Reference strains improve reproducibility by standardizing observations and methodology,
which has ultimately led to important insights into fungal pathogenesis. However, recent …

We examined the changes in genotypes and azole susceptibilities among sequential
bloodstream isolates of Candida glabrata during the course of fungemia and the relationship …

Resistance to azole drugs, the major clinical antifungal compounds, is most commonly due
to gain‐of‐function (GOF) substitution mutations in a gene called PDR1 in the fungal …