Numerous variations on structural motifs exist within pharmaceutical compounds that have
entered the clinic. These variations have amounted over many decades based on years of …

Drug delivery is a rapidly growing area of research motivated by the nanotechnology
revolution, the ideal of personalized medicine, and the desire to reduce the side effects of …

The therapeutic efficacy of nanoscale anticancer drug delivery systems is severely truncated
by their low tumor-targetability and inefficient drug release at the target site. Here, we report …

Endosomal pH-activatable paclitaxel (PTX) prodrug micellar nanoparticles were designed
and prepared by conjugating PTX onto water-soluble poly (ethylene glycol)-b-poly (acrylic …

Multi-drug delivery focuses on different signaling pathways in cancer cells that have
synergistic anti-proliferative effects. In this study, we developed multi-prodrug nanocarriers …

Cancer, a multifaceted and diverse ailment, presents formidable obstacles to traditional
treatment modalities. Nanotechnology presents novel prospects for surmounting these …

Paclitaxel belongs to the most successful anticancer drugs developed and utilised during
the past two decades. Nevertheless, the development of resistance of tumor cells and …

Introduction: Advances in cancer therapeutics, namely more effective and less toxic
treatments, will occur with targeting strategies that enhance the tumor biodistribution and …

Graph theoretical molecular descriptors alias topological indices are a convenient means for
expressing in numerical form the chemical structure encoded in a molecular graph. The …

Brain (central nervous system; CNS) metastases pose a life-threatening problem for women
with advanced metastatic breast cancer. It has recently been shown that the vasculature …