Ferrets are widely employed to study the pathogenicity, transmissibility, and tropism of
influenza viruses. However, inherent variations in inoculation methods, sampling schemes …

Influenza virus infections are a significant cause of morbidity and mortality in the human
population. Depending on the virulence of the influenza virus strain, as well as the …

Seasonal influenza viruses cause major morbidity and mortality worldwide, threatening in
particular older adults and the immunocompromised. Two classes of influenza therapeutics …

In vivo assessments of influenza A virus (IAV) pathogenicity and transmissibility in ferrets
represent a crucial component of many pandemic risk assessment rubrics, but few …

Data from influenza A virus (IAV) infected ferrets provides invaluable information towards the
study of novel and emerging viruses that pose a threat to human health. This gold standard …

The concern of the emergence of a pandemic influenza virus has sparked an increased
effort toward the development and testing of novel influenza antivirals. Central to this is the …

As use of the ferret model to study influenza A virus (IAV) pathogenicity increases, periodic
assessment of data generated in this model is warranted, to identify features associated with …

Viral pathogenesis and therapeutic screening studies that utilize small mammalian models
rely on the accurate quantification and interpretation of morbidity measurements, such as …

As influenza A viruses (IAV) continue to cross species barriers and cause human infection,
the establishment of risk assessment rubrics has improved pandemic preparedness efforts …

As influenza viruses continue to jump species barriers to cause human infection,
assessments of disease severity and viral replication kinetics in vivo provide crucial …