Deuterium‐and tritium‐labelled compounds: applications in the life sciences

J Atzrodt, V Derdau, WJ Kerr… - Angewandte chemie …, 2018 - Wiley Online Library
Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …

LC-MS-based metabolomics

B Zhou, JF **ao, L Tuli, HW Ressom - Molecular BioSystems, 2012 - pubs.rsc.org
Metabolomics aims at identification and quantitation of small molecules involved in
metabolic reactions. LC-MS has enjoyed a growing popularity as the platform for …

Toxicity mechanisms of polystyrene microplastics in marine mussels revealed by high-coverage quantitative metabolomics using chemical isotope labeling liquid …

W Huang, X Wang, D Chen, EG Xu, X Luo… - Journal of hazardous …, 2021 - Elsevier
Marine microplastic has become an important environmental issue of global concern due to
its wide distribution and harmful impacts. However, there is still insufficient information on …

An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography–tandem mass spectrometry

J Han, K Lin, C Sequeira, CH Borchers - Analytica chimica acta, 2015 - Elsevier
Short-chain fatty acids (SCFAs) are produced by anaerobic gut microbiota in the large
bowel. Qualitative and quantitative measurements of SCFAs in the intestinal tract and the …

Mass spectrometric based approaches in urine metabolomics and biomarker discovery

MM Khamis, DJ Adamko… - Mass spectrometry …, 2017 - Wiley Online Library
Urine metabolomics has recently emerged as a prominent field for the discovery of non‐
invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific …

Metabolomic coverage of chemical-group-submetabolome analysis: group classification and four-channel chemical isotope labeling LC-MS

S Zhao, H Li, W Han, W Chan, L Li - Analytical Chemistry, 2019 - ACS Publications
Chemical isotope labeling (CIL) liquid chromatography mass spectrometry (LC-MS) is a
powerful technique for in-depth metabolome analysis with high quantification accuracy …

Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks

A Chokkathukalam, DH Kim, MP Barrett, R Breitling… - Bioanalysis, 2014 - Taylor & Francis
The rapid emergence of metabolomics has enabled system-wide measurements of
metabolites in various organisms. However, advances in the mechanistic understanding of …

Advances and perspectives in chemical isotope labeling-based mass spectrometry methods for metabolome and exposome analysis

S Gao, X Zhou, M Yue, S Zhu, Q Liu, XE Zhao - TrAC Trends in Analytical …, 2023 - Elsevier
Metabolomics and exposomics are important in the studies of human health and diseases.
Chemical isotope labeling (CIL) combined with mass spectrometry (MS) can not only …

MyCompoundID: using an evidence-based metabolome library for metabolite identification

L Li, R Li, J Zhou, A Zuniga, AE Stanislaus… - Analytical …, 2013 - ACS Publications
Identification of unknown metabolites is a major challenge in metabolomics. Without the
identities of the metabolites, the metabolome data generated from a biological sample …

Fast quantification of short chain fatty acids and ketone bodies by liquid chromatography-tandem mass spectrometry after facile derivatization coupled with liquid …

M Zeng, H Cao - Journal of Chromatography B, 2018 - Elsevier
Short chain fatty acids (SCFA) and ketone bodies recently emerged as important
physiological relevant metabolites because of their association with microbiota …