Malaria is possibly the most serious infectious disease of humans, infecting 5–10% of the
world's population, with 300–600 million clinical cases and more than 2 million deaths …

The persistence of the human malaria parasite Plasmodium falciparum during blood stage
proliferation in its host depends on the successive expression of variant molecules at the …

Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for
HIV/AIDS, Tuberculosis, and Malaria | PLOS Medicine Skip to main content Advertisement …

Background Severe malaria (SM) is classically associated with Plasmodium falciparum
infection. Little information is available on the contribution of P. vivax to severe disease …

Innate, inflammation-based immunity is the first line of vertebrate defence against micro-
organisms. Inflammation relies on a number of cellular and molecular effectors that can …

Sequestration of malaria-parasite-infected erythrocytes in the microvasculature of organs is
thought to be a significant cause of pathology. Cerebral malaria (CM) is a major …

C1 inhibitor (C1INH) is a serpin that regulates both complement and contact (kallikrein-kinin)
system activation. It consists of a serpin domain that is highly homologous to other serpins …

Intracellular pathogens have devised mechanisms to exploit their host cells to ensure their
survival and replication. The malaria parasite Plasmodium falciparum relies on an exchange …

The inner membrane complex (IMC) of Toxoplasma gondii is a peripheral membrane system
that is composed of flattened alveolar sacs that underlie the plasma membrane, coupled to a …

Malaria represents a continuing and major global health challenge and our understanding
of how the Plasmodium parasite causes severe disease and death remains poor. One …