Packaging of eukaryotic genome into chromatin is a major obstacle to cells encountering
DNA damage caused by external or internal agents. For maintaining genomic integrity, the …

The DNA damage response (DDR) is essential for maintaining genome integrity. Mounting
evidence reveals that protein modifications play vital roles in the DDR. Here, we show that …

Histone post-translational modifications play pivotal roles in eukaryotic gene expression. To
date, most studies have focused on modifications in unstructured histone N-terminal tail …

A broad spectrum of spontaneous and genotoxin-induced DNA lesions impede replication
fork progression. The DNA damage response that acts to promote completion of DNA …

Bivalent chromatin domains containing repressive H3K27me3 and active H3K4me3
modifications are barriers for the expression of lineage-specific genes in ES cells and must …

ABSTRACT H3K56 acetylation (H3K56Ac) was first identified in yeast and has recently been
reported to play important roles in maintaining genomic stability, chromatin assembly, DNA …

Histone acetyltransferases (HATs) are a class of epigenetic enzymes involved in critical
cellular processes like nucleosome assembly, DNA damage repair, and transcriptional …

The mammalian FACT complex is a highly conserved histone chaperone with essential
roles in transcription elongation, histone deposition, and maintenance of stem cell state …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are well-known for their effects on
inflammatory gene expression. Although NSAIDs are known to impact multiple cellular …

Acetylated histone H3 lysine 56 (H3K56Ac) diminishes in response to DNA damage but is
restored following DNA repair. Here, we report that CRL4DDB2 ubiquitin ligase …