[HTML][HTML] Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration

PR Freitas, ACJ de Araújo, IM Araújo… - Biomedicine & …, 2024 - Elsevier
Staphylococcus aureus is a bacterium responsible for resistance to multiple drugs and the
efflux system is widely studied among the resistance mechanisms developed by this …

Insights into bacterial interactions: Comparing fluorine-containing 1, 2, 4-triazoles to antibiotics using molecular docking and molecular dynamics approaches

N Korol, O Holovko-Kamoshenkova, R Mariychuk… - Heliyon, 2024 - cell.com
Understanding the interactions between drugs and enzymes is crucial for designing effective
therapeutics. This study employed a combination of molecular docking and molecular …

[HTML][HTML] Stapled Peptides: An Innovative and Ultimate Future Drug Offering a Highly Powerful and Potent Therapeutic Alternative

DH Kim, SM Kang - Biomimetics, 2024 - mdpi.com
Peptide-based therapeutics have traditionally faced challenges, including instability in the
bloodstream and limited cell membrane permeability. However, recent advancements in α …

Assessment In vitro and In silico of the Activity of Thiadiazines as NorA Efflux Pump Inhibitors

ACJ de Araújo, PR Freitas, IM Araújo… - Current …, 2024 - Springer
Antimicrobials fight microorganisms, preventing and treating infectious diseases. However,
antimicrobial resistance (AMR) is a growing concern due to the inappropriate and excessive …

Identification of antibiotic-resistance markers of Edwardsiella tarda using aptamers

Y Fan, J Zheng, M Lin, Q Weng, L Huang, Q Yan - Food Bioscience, 2024 - Elsevier
Edwardsiella tarda poses significant challenges in the aquaculture sector due to its antibiotic
resistance, leading to substantial economic loss in the aquaculture industry. Therefore, it is …

Evaluating efflux pump inhibition in Staphylococcus aureus 1199B strain using thiadiazine-derived compounds: In vitro and in silico approaches

PR Freitas, ACJ de Araújo, IM Araújo, RS Almeida… - Biochimie, 2024 - Elsevier
Thiadiazines are heterocyclic compounds known for some pharmacological activities.
However, the ability of these compounds and their derivatives to act as antibacterial agents …

Assessment of MepA inhibition potential using thiadiazine derivatives through fluorometry, docking, and qPCR

ACJ de Araújo, PR Freitas, IM Araújo… - Gene Reports, 2025 - Elsevier
Antibiotics are crucial in treating infectious diseases, but bacterial resistance is a serious
public health issue, increasing costs and prolonging treatments. Staphylococcus aureus (S …

IDENTIFICATION OF QUINOLONE-TRAIZOLE HYBRIDS AS POTENTIAL INHIBITORS USING IN SILICO APPROACH

SA Ejaz, AA Alsfouk, T Shamim, L Sumreen… - Química …, 2024 - SciELO Brasil
Alzheimer's disease (AD) is a most common form of dementia and results in memory loss,
disorientation, impaired thinking and changes in personality as well as mood. The dementia …

[PDF][PDF] Proceeding Book

G Çuvalcıoğlu, APDF Tuğrul - 2024 - ifscom.com
Welcome to the Tenth International Conference on IFS and Contemporary Mathematics and
Engineering (IFSCOM-E 2024). The aim of our conference is to bring together important …

THE POTENTIAL OF GINSENOSIDES AS AN ALTERNATIVE TO ANTHRACYCLINES IN BREAST CANCER TREATMENT: AN IN SILICO STUDY

NİL SAZLI, D KARATAŞ - 10th International IFS and …, 2024 - researchgate.net
In this paper, the drug potential of Rh1 and Rh3 ginsenosides, which are alternatives to the
anthracyclines daunorubicin, doxorubicin, epirubicin, idarubicin, and mitoxantrone …