▪ Abstract The conjugation of ubiquitin to other cellular proteins regulates a broad range of
eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination …

Annexins are Ca2+ and phospholipid binding proteins forming an evolutionary conserved
multigene family with members of the family being expressed throughout animal and plant …

Ubiquitylation? the conjugation of proteins with a small protein called ubiquitin? touches
upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases …

The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and
targets them for degradation or for other cellular fates. The HECT enzymes, including Nedd4 …

Endocytosis of cell surface receptors is an important regulatory event in signal transduction.
The transforming growth factor β (TGF-β) superfamily signals to the Smad pathway through …

The internalization of various cargo proteins and lipids from the mammalian cell surface
occurs through the clathrin and lipid-raft endocytic pathways. Protein–lipid and protein …

Neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4) is the
prototypical protein in a family of E3 ubiquitin ligases that have a common domain …

Sustained calcium signaling induces a state of anergy or antigen unresponsiveness in T
cells, mediated through calcineurin and the transcription factor NFAT. We show here that …

Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …

The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family
of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with …