Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular
homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic …

Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …

We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC).
Using this dataset, we expand the catalogue of known ACC driver genes to include …

Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

Cells use mitophagy to remove dysfunctional or excess mitochondria, frequently in response
to imposed stresses, such as hypoxia and nutrient deprivation. Mitochondrial cargo …

Autophagy is a genetically well-controlled cellular process that is tightly controlled by a set of
core genes, including the family of autophagy-related genes (ATG). Autophagy is a “double …