Cell segmentation methods for label-free contrast microscopy: review and comprehensive comparison

T Vicar, J Balvan, J Jaros, F Jug, R Kolar, M Masarik… - BMC …, 2019 - Springer
Background Because of its non-destructive nature, label-free imaging is an important
strategy for studying biological processes. However, routine microscopic techniques like …

Label-free live cell recognition and tracking for biological discoveries and translational applications

B Chen, Z Yin, BWL Ng, DM Wang, RS Tuan, R Bise… - npj Imaging, 2024 - nature.com
Label-free, live cell recognition (ie instance segmentation) and tracking using computer
vision-aided recognition can be a powerful tool that rapidly generates multi-modal readouts …

Topological defects in epithelia govern cell death and extrusion

TB Saw, A Doostmohammadi, V Nier, L Kocgozlu… - Nature, 2017 - nature.com
Epithelial tissues (epithelia) remove excess cells through extrusion, preventing the
accumulation of unnecessary or pathological cells. The extrusion process can be triggered …

[HTML][HTML] Usiigaci: Instance-aware cell tracking in stain-free phase contrast microscopy enabled by machine learning

HF Tsai, J Gajda, TFW Sloan, A Rares, AQ Shen - SoftwareX, 2019 - Elsevier
Stain-free, single-cell segmentation and tracking is tantamount to the holy grail of
microscopic cell migration analysis. Phase contrast microscopy (PCM) images with cells at …

Ore image segmentation method using U-Net and Res_Unet convolutional networks

X Liu, Y Zhang, H **g, L Wang, S Zhao - RSC advances, 2020 - pubs.rsc.org
Image segmentation has been increasingly used to identify the particle size distribution of
crushed ore; however, the adhesion of ore particles and dark areas in the images of blast …

Deep learning predicts function of live retinal pigment epithelium from quantitative microscopy

NJ Schaub, NA Hotaling, P Manescu… - The Journal of …, 2020 - Am Soc Clin Investig
Increases in the number of cell therapies in the preclinical and clinical phases have
prompted the need for reliable and noninvasive assays to validate transplant function in …

Endothelial basement membrane laminin 511 is essential for shear stress response

J Di Russo, AL Luik, L Yousif, S Budny… - The EMBO …, 2017 - embopress.org
Shear detection and mechanotransduction by arterial endothelium requires junctional
complexes containing PECAM‐1 and VE‐cadherin, as well as firm anchorage to the …

Weakly supervised cell instance segmentation under various conditions

K Nishimura, C Wang, K Watanabe, R Bise - Medical Image Analysis, 2021 - Elsevier
Cell instance segmentation is important in biomedical research. For living cell analysis,
microscopy images are captured under various conditions (eg, the type of microscopy and …

Learn to segment single cells with deep distance estimator and deep cell detector

W Wang, DA Taft, YJ Chen, J Zhang, CT Wallace… - Computers in biology …, 2019 - Elsevier
Single cell segmentation is a critical and challenging step in cell imaging analysis.
Traditional processing methods require time and labor to manually fine-tune parameters and …

Effective pseudo-labeling based on heatmap for unsupervised domain adaptation in cell detection

H Cho, K Nishimura, K Watanabe, R Bise - Medical Image Analysis, 2022 - Elsevier
Cell detection is an important task in biomedical research. Recently, deep learning methods
have made it possible to improve the performance of cell detection. However, a detection …