Macrophages are present in all vertebrate tissues, from mid-gestation throughout life,
constituting a widely dispersed organ system. They promote homeostasis by responding to …

The development of high-throughput RNA sequencing (RNA-seq) at the single-cell level has
already led to profound new discoveries in biology, ranging from the identification of novel …

Abstract Mouse Genome Informatics (MGI) is a federation of expertly curated information
resources designed to support experimental and computational investigations into genetic …

The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …

Spatial patterns of gene expression manifest at scales ranging from local (eg, cell-cell
interactions) to global (eg, body axis patterning). However, current spatial transcriptomics …

Single-cell RNA sequencing (scRNA-seq) technologies are poised to reshape the current
cell-type classification system. However, a transcriptome-based single-cell atlas has not …

Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …

Neural crest cells are embryonic progenitors that generate numerous cell types in
vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become …

The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and
forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP …

The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of
GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess …