Programmed cell death in aging
J Tower - Ageing research reviews, 2015 - Elsevier
Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …
Links between metabolism and cancer
CV Dang - Genes & development, 2012 - genesdev.cshlp.org
Metabolism generates oxygen radicals, which contribute to oncogenic mutations. Activated
oncogenes and loss of tumor suppressors in turn alter metabolism and induce aerobic …
oncogenes and loss of tumor suppressors in turn alter metabolism and induce aerobic …
The human cell count and size distribution
Cell size and cell count are adaptively regulated and intimately linked to growth and
function. Yet, despite their widespread relevance, the relation between cell size and count …
function. Yet, despite their widespread relevance, the relation between cell size and count …
Metabolic regulation of species-specific developmental rates
Animals display substantial inter-species variation in the rate of embryonic development
despite a broad conservation of the overall sequence of developmental events. Differences …
despite a broad conservation of the overall sequence of developmental events. Differences …
[HTML][HTML] A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals
Differential speeds in biochemical reactions have been proposed to be responsible for the
differences in developmental tempo between mice and humans. However, the underlying …
differences in developmental tempo between mice and humans. However, the underlying …
Single-cell–resolution map of human retinal pigment epithelium helps discover subpopulations with differential disease sensitivity
Regional phenotypic and functional differences in the retinal pigment epithelium (RPE)
monolayer have been suggested to account for regional susceptibility in ocular diseases …
monolayer have been suggested to account for regional susceptibility in ocular diseases …
Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration
Background The size of organs and tissues is basically determined by the number and size
of their cells. However, little attention has been paid to this fundamental concept. The liver …
of their cells. However, little attention has been paid to this fundamental concept. The liver …
Small and mighty: adaptation of superphylum Patescibacteria to groundwater environment drives their genome simplicity
Background The newly defined superphylum Patescibacteria such as Parcubacteria (OD1)
and Microgenomates (OP11) has been found to be prevalent in groundwater, sediment …
and Microgenomates (OP11) has been found to be prevalent in groundwater, sediment …
Mechanism-based concepts of size and maturity in pharmacokinetics
Growth and development can be investigated using readily observable demographic factors
such as weight and age. Size is the primary covariate and can be referenced to a 70-kg …
such as weight and age. Size is the primary covariate and can be referenced to a 70-kg …
Canine mammary tumors as a model for human disease
SM Abdelmegeed, S Mohammed - Oncology letters, 2018 - spandidos-publications.com
Animal models for examining human breast cancer (HBC) carcinogenesis have been
extensively studied and proposed. With the recent advent of immunotherapy, significant …
extensively studied and proposed. With the recent advent of immunotherapy, significant …