Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …

Chalcones, containing an α, β-unsaturated ketone fragment, are an important
pharmacologically active agents because of their diverse mechanisms. This review provides …

The emergence of multi-drug-resistant bacteria is threatening to human health and life
around the world. In particular, methicillin-resistant Staphylococcus aureus (MRSA) causes …

Cancer is known as one of the main causes of death in the world; and many compounds
have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile …

The widespread use of antibiotics has made the problem of bacterial resistance increasingly
serious, and the study of new drug-resistant bacteria has become the main direction of …

A hybrid pharmacophore approach was adopted to design and synthesize new series of
pyridone-thiazole hybrid compounds. The structures of the compounds were established by …

Abstract Reaction of 5-morphilinosulfonylisatin (1) with acetophenones (2a–e) afforded 3-
hydroxy-3-substituted-2-oxoindoles 3a-e, when treated with acetic acid the expected 3 …

Abstract Development of new antimicrobial agents is a good solution to overcome drug-
resistance problems. In this context, new functionalized thiophene, acrylamide …

In the present investigation, a series of 3-(1-(2-(thiazol-2-yl) hydrazineylidene) ethyl)-2H-
chromen-2-one derivatives are synthesized in good to excellent yield using PEG-400 as a …

Thiazole is the most common heterocyclic compound in heterocyclic chemistry and in drug
design. Presence of several reaction sites in the thiazole moiety extends their range of …