[HTML][HTML] Theory and implementation of inelastic constitutive artificial neural networks

H Holthusen, L Lamm, T Brepols, S Reese… - Computer Methods in …, 2024 - Elsevier
The two fundamental concepts of materials theory, pseudo potentials and the assumption of
a multiplicative decomposition, allow a general description of inelastic material behavior …

[HTML][HTML] Best-in-class modeling: A novel strategy to discover constitutive models for soft matter systems

K Linka, E Kuhl - Extreme Mechanics Letters, 2024 - Elsevier
The ability to automatically discover interpretable mathematical models from data could
forever change how we model soft matter systems. For convex discovery problems with a …

Inelastic material formulations based on a co-rotated intermediate configuration—application to bioengineered tissues

H Holthusen, C Rothkranz, L Lamm, T Brepols… - Journal of the …, 2023 - Elsevier
In the field of material modeling, there is a general trend to include more and more complex
phenomena in the modeling, making the models' theoretical derivation and numerical …

Arterial tissues and their inflammatory response to collagen damage: a continuum in silico model coupling nonlinear mechanics, molecular pathways, and cell …

M Gierig, P Wriggers, M Marino - Computers in Biology and Medicine, 2023 - Elsevier
Damage in soft biological tissues causes an inflammatory reaction that initiates a chain of
events to repair the tissue. This work presents a continuum model and its in silico …

[HTML][HTML] Automated model discovery for tensional homeostasis: Constitutive machine learning in growth and remodeling

H Holthusen, T Brepols, K Linka, E Kuhl - Computers in Biology and …, 2025 - Elsevier
We present a built-in physics neural network architecture, known as inelastic Constitutive
Artificial Neural Network (iCANN), to discover the inelastic phenomenon of tensional …

Machine learning-based prediction of In-Stent restenosis risk using systemic inflammation aggregation index following coronary stent Placement

L Hou, J Zhao, T He, K Su, Y Li - Risk Management and …, 2024 - Taylor & Francis
Introduction Coronary artery disease (CAD) remains a significant global health challenge,
with percutaneous coronary intervention (PCI) being a primary revascularization method. In …

[HTML][HTML] Post-angioplasty remodeling of coronary arteries investigated via a chemo-mechano-biological in silico model

M Gierig, P Gaziano, P Wriggers, M Marino - Journal of Biomechanics, 2024 - Elsevier
This work presents the application of a chemo-mechano-biological constitutive model of soft
tissues for describing tissue inflammatory response to damage in collagen constituents. The …

Computational modeling of in-stent restenosis: Pharmacokinetic and pharmacodynamic evaluation

K Manjunatha, N Schaaps, M Behr, F Vogt… - Computers in Biology …, 2023 - Elsevier
Persistence of the pathology of in-stent restenosis even with the advent of drug-eluting
stents warrants the development of highly resolved in silico models. These computational …

Mechanical modeling of the maturation process for tissue-engineered implants: Application to biohybrid heart valves

M Sesa, H Holthusen, L Lamm, C Böhm… - Computers in Biology …, 2023 - Elsevier
The development of tissue-engineered cardiovascular implants can improve the lives of
large segments of our society who suffer from cardiovascular diseases. Regenerative …

Lifelike Transformative Materials for Biohybrid Implants: Inspired by Nature, Driven by Technology

A Fernández‐Colino, F Kiessling… - Advanced …, 2023 - Wiley Online Library
Today's living world is enriched with a myriad of natural biological designs, shaped by
billions of years of evolution. Unraveling the construction rules of living organisms offers the …