Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis,
injury of the alveolar epithelium and endothelium, hyaline membrane formation, and …

Pseudomonas aeruginosa is an important pathogen causing a wide range of acute and
chronic infections. P. aeruginosa rarely causes infection in the normal host, but is an efficient …

Sepsis and the acute respiratory distress syndrome (ARDS) are major causes of mortality
without targeted therapies. Although many experimental and clinical observations have …

A decrease in the activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) increases
the amount of low-density lipoprotein (LDL) receptors on liver cells and, therefore, LDL …

Ligands from dying cells are a source of Toll-like receptor (TLR) activating agents. Although
TLR3 is known to respond to RNA from necrotic cells, the relative importance of this …

Virtually of the all recent therapeutic interventions for treating sepsis have failed to improve
survival. One potential explanation is that the heterogeneity of the immune response to the …

Leptin is an adipocyte-derived hormone that is secreted in correlation with total body lipid
stores. Serum leptin levels are lowered by the loss of body fat mass that would accompany …

Cytokines are produced during the activation of innate and acquired immunity, and are the
principal means for intercellular communication of a microbial invasion. Cytokines serve to …

Pseudomonas aeruginosa (P. aeruginosa) is a common organism associated with bacterial
keratitis, especially in those who use extended wear contact lenses. Recent advances in our …

Abstract Interleukin (IL)-10 is a pleiotropic cytokine produced by both T cells and
macrophages and possesses both anti-inflammatory and immunosuppressive properties. IL …