Medical physics challenges in clinical MR-guided radiotherapy

C Kurz, G Buizza, G Landry, F Kamp, M Rabe… - Radiation …, 2020 - Springer
The integration of magnetic resonance imaging (MRI) for guidance in external beam
radiotherapy has faced significant research and development efforts in recent years. The …

Variability and standardization of quantitative imaging: monoparametric to multiparametric quantification, radiomics, and artificial intelligence

A Hagiwara, S Fujita, Y Ohno, S Aoki - Investigative radiology, 2020 - journals.lww.com
Radiological images have been assessed qualitatively in most clinical settings by the expert
eyes of radiologists and other clinicians. On the other hand, quantification of radiological …

Multiparametric MRI for characterization of the tumour microenvironment

E Hoffmann, M Masthoff, WG Kunz… - Nature Reviews …, 2024 - nature.com
Our understanding of tumour biology has evolved over the past decades and cancer is now
viewed as a complex ecosystem with interactions between various cellular and non-cellular …

Improved unsupervised physics‐informed deep learning for intravoxel incoherent motion modeling and evaluation in pancreatic cancer patients

MPT Kaandorp, S Barbieri, R Klaassen… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose Earlier work showed that IVIM‐NETorig, an unsupervised physics‐informed deep
neural network, was faster and more accurate than other state‐of‐the‐art intravoxel …

ADC measurements on the Unity MR-linac–A recommendation on behalf of the Elekta Unity MR-linac consortium

ES Kooreman, PJ van Houdt, R Keesman… - Radiotherapy and …, 2020 - Elsevier
Background and purpose Diffusion-weighted imaging (DWI) for treatment response
monitoring is feasible on hybrid magnetic resonance linear accelerator (MR-linac) systems …

Quantitative magnetic resonance imaging for biological image-guided adaptive radiotherapy

PJ Van Houdt, Y Yang, UA Van der Heide - Frontiers in Oncology, 2021 - frontiersin.org
MRI-guided radiotherapy systems have the potential to bring two important concepts in
modern radiotherapy together: adaptive radiotherapy and biological targeting. Based on …

Linearity and bias of proton density fat fraction as a quantitative imaging biomarker: a multicenter, multiplatform, multivendor phantom study

HH Hu, T Yokoo, MR Bashir, CB Sirlin, D Hernando… - Radiology, 2021 - pubs.rsna.org
Background Proton density fat fraction (PDFF) estimated by using chemical shift–encoded
(CSE) MRI is an accepted imaging biomarker of hepatic steatosis. This work aims to promote …

The future of MRI in radiation therapy: Challenges and opportunities for the MR community

RJ Goodburn, MEP Philippens… - Magnetic resonance …, 2022 - Wiley Online Library
Radiation therapy is a major component of cancer treatment pathways worldwide. The main
aim of this treatment is to achieve tumor control through the delivery of ionizing radiation …

Development, validation, qualification, and dissemination of quantitative MR methods: overview and recommendations by the ISMRM quantitative MR study group

S Weingärtner, KL Desmond… - Magnetic …, 2022 - Wiley Online Library
On behalf of the International Society for Magnetic Resonance in Medicine (ISMRM)
Quantitative MR Study Group, this article provides an overview of considerations for the …

[HTML][HTML] Integration of quantitative imaging biomarkers in clinical trials for MR-guided radiotherapy: Conceptual guidance for multicentre studies from the MR-Linac …

PJ van Houdt, H Saeed, D Thorwarth, CD Fuller… - European Journal of …, 2021 - Elsevier
Quantitative imaging biomarkers (QIBs) derived from MRI techniques have the potential to
be used for the personalised treatment of cancer patients. However, large-scale data are …