Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …

The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …

Abstract Structure determination of linear peptides of 5–50 amino acids in aqueous solution
and interacting with proteins is a key aspect in structural biology. PEP-FOLD3 is a novel …

Venoms have evolved on numerous occasions throughout the animal kingdom. These
'biochemical weapon systems' typically function to facilitate, or protect the producing animal …

Venomous animals have evolved toxins that interfere with specific components of their
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …

This minireview touches upon the challenges and opportunities peptides experience on the
track to become an approved pharmaceutical. Peptide attributes originally considered …

In the context of the renewed interest of peptides as therapeutics, it is important to have an
on-line resource for 3D structure prediction of peptides with well-defined structures in …

Introduction: An extraordinarily diverse range of animals have evolved venoms for predation,
defence, or competitor deterrence. The major components of most venoms are peptides and …

Spider venoms are an incredibly rich source of disulfide-rich insecticidal peptides that have
been tuned over millions of years to target a wide range of receptors and ion channels in the …

Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action
potentials and served as an early muse for biophysicists laying the foundation for our current …