Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Abstract The Hedgehog (Hh) signalling pathway plays many important roles in development,
homeostasis and tumorigenesis. The critical function of Hh signalling in bone formation has …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

The formation of the face and skull involves a complex series of developmental events
mediated by cells derived from the neural crest, endoderm, mesoderm, and ectoderm …

Abstract Cleidocranial dysplasia (CCD,# 119600), which is characterized by hypoplastic
clavicles, open fontanelles, supernumerary teeth and a short stature, is caused by …

The zebrafish is as an important vertebrate animal model system for studying developmental
processes, gene functions and signalling pathways. It is also used as a model system for the …

Bone is a connective tissue composed of many cell types, including osteoblasts. How bones
acquire their unique size and shape during development remains poorly understood. Herein …

Osteoblast differentiation from mesenchymal cells is regulated by multiple signalling
pathways. Here we have analysed the roles of Fibroblast Growth Factor (FGF) and canonical …

Zebrafish innately regenerate amputated fins by mechanisms that expand and precisely
position injury-induced progenitor cells to re-form tissue of the original size and pattern. For …

The healing of bone often involves a cartilage intermediate, yet how such cartilage is
induced and utilized during repair is not fully understood. By studying a model of large-scale …