In this review, we focus on recent developments in our understanding of nutrient-induced
insulin secretion that challenge a key aspect of the" canonical" model, in which an oxidative …

Diabetes is the most common metabolic disorder, with an extremely serious effect on health
systems worldwide. It has become a severe, chronic, non-communicable disease after …

Deoxynivalenol (DON) is one of the most plentiful trichothecenes occurring in food and feed,
which brings severe health hazards to both animals and humans. This study aims to …

Pancreatic β cells couple nutrient metabolism with appropriate insulin secretion. Here, we
show that pyruvate kinase (PK), which converts ADP and phosphoenolpyruvate (PEP) into …

Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-
stimulated K ATP channel closure and insulin secretion. To identify the PK isoforms …

MODY8 (maturity-onset diabetes of the young, type 8) is a dominantly inherited monogenic
form of diabetes associated with mutations in the carboxyl ester lipase (CEL) gene …

Summary The ATP-sensitive K+(K ATP) channel is a key regulator of hormone secretion
from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in …

An agreed-upon consensus model of glucose-stimulated insulin secretion from healthy β-
cells is essential for understanding diabetes pathophysiology. Since the discovery of the …

We hypothesize that basal hyperinsulinemia is synergistically mediated by an interplay
between increased oxidative stress and excess lipid in the form of reactive oxygen species …

Pancreatic islet β-cells exhibit tremendous plasticity for secretory adaptations that coordinate
insulin production and release with nutritional demands. This essential feature of the β-cell …