[HTML][HTML] Kidney and eye diseases: common risk factors, etiological mechanisms, and pathways

CW Wong, TY Wong, CY Cheng, C Sabanayagam - Kidney international, 2014 - Elsevier
Chronic kidney disease is an emerging health problem worldwide. The eye shares striking
structural, developmental, and genetic pathways with the kidney, suggesting that kidney …

Medical management of glaucoma in the 21st century from a Canadian perspective

P Harasymowycz, C Birt, P Gooi… - Journal of …, 2016 - Wiley Online Library
Glaucoma is a medical term describing a group of progressive optic neuropathies
characterized by degeneration of retinal ganglion cells and retinal nerve fibre layer and …

Epidemiology of glaucoma in sub-saharan Africa: prevalence, incidence and risk factors

F Kyari, MM Abdull, A Bastawrous… - Middle East African …, 2013 - journals.lww.com
Purpose: The purpose of this study is to review the epidemiology of different types of
glaucoma relevant to Sub-Saharan Africa (SSA) and to discuss the evidence regarding the …

Sustained release ocular drug delivery systems for glaucoma therapy

ZK Al-Qaysi, IG Beadham, SL Schwikkard… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Glaucoma is a group of progressive optic neuropathies resulting in irreversible
blindness. It is associated with an elevation of intraocular pressure (> 21 mm Hg) and optic …

All roads lead to glaucoma: Induced retinal injury cascades contribute to a common neurodegenerative outcome

S Alqawlaq, JG Flanagan, JM Sivak - Experimental eye research, 2019 - Elsevier
Glaucoma describes a distinct optic neuropathy with complex etiology and a variety of
associated risk factors, but with similar pathological endpoints. Risk factors such as age …

[HTML][HTML] Topical Coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension

BM Davis, K Tian, M Pahlitzsch, J Brenton… - Mitochondrion, 2017 - Elsevier
Abstract Coenzyme Q10 (CoQ10) is a mitochondrial-targeted antioxidant with known
neuroprotective activity. Its ocular effects when co-solubilised with α–tocopherol …

Tetrahedral framework nucleic acids prevent retina ischemia-reperfusion injury from oxidative stress via activating the Akt/Nrf2 pathway

X Qin, N Li, M Zhang, S Lin, J Zhu, D **ao, W Cui… - Nanoscale, 2019 - pubs.rsc.org
Retinal ischemia-reperfusion (I/R) injuries are involved in the universal pathological
processes of many ophthalmic diseases, including glaucoma, diabetic retinopathy, and …

[HTML][HTML] Sphingolipids as critical players in retinal physiology and pathology

MV Simon, SK Basu, B Qaladize, R Grambergs… - Journal of Lipid …, 2021 - Elsevier
Sphingolipids have emerged as bioactive lipids involved in the regulation of many
physiological and pathological processes. In the retina, they have been established to …

Intracameral sustained-release bimatoprost implant delivers bimatoprost to target tissues with reduced drug exposure to off-target tissues

JR Seal, MR Robinson, J Burke… - Journal of Ocular …, 2019 - liebertpub.com
Purpose: To explore the ocular distribution of bimatoprost after intracameral administration
of a biodegradable sustained-release bimatoprost implant (Bimatoprost SR) versus …

The role of neuroinflammation in glaucoma: an update on molecular mechanisms and new therapeutic options

T Rolle, A Ponzetto, L Malinverni - Frontiers in Neurology, 2021 - frontiersin.org
Glaucoma is a multifactorial optic neuropathy characterized by the continuous loss of retinal
ganglion cells, leading to progressive and irreversible visual impairment. In this minireview …