Dopamine: functions, signaling, and association with neurological diseases
The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …
[HTML][HTML] Vascular nitric oxide: Beyond eNOS
Y Zhao, PM Vanhoutte, SWS Leung - Journal of pharmacological sciences, 2015 - Elsevier
As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of
cellular processes, including those involving vascular cells. This brief review summarizes …
cellular processes, including those involving vascular cells. This brief review summarizes …
GPCR activation and GRK2 assembly by a biased intracellular agonist
J Duan, H Liu, F Zhao, Q Yuan, Y Ji, X Cai, X He, X Li… - Nature, 2023 - nature.com
Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs)
desensitizes G-protein signalling and promotes arrestin signalling, which is also modulated …
desensitizes G-protein signalling and promotes arrestin signalling, which is also modulated …
CCR6-CCL20 axis as a therapeutic target for autoimmune diseases
Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …
[HTML][HTML] Identification of phosphorylation codes for arrestin recruitment by G protein-coupled receptors
G protein-coupled receptors (GPCRs) mediate diverse signaling in part through interaction
with arrestins, whose binding promotes receptor internalization and signaling through G …
with arrestins, whose binding promotes receptor internalization and signaling through G …
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins.
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1
G-protein-coupled receptor (GPCR) kinases (GRKs) selectively phosphorylate activated
GPCRs, thereby priming them for desensitization. Although it is unclear how GRKs …
GPCRs, thereby priming them for desensitization. Although it is unclear how GRKs …
Post-translational modifications of G Protein–Coupled receptors control cellular signaling dynamics in space and time
G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
GPCR desensitization: Acute and prolonged phases
S Rajagopal, SK Shenoy - Cellular signalling, 2018 - Elsevier
G protein-coupled receptors (GPCRs) transduce a wide array of extracellular signals and
regulate virtually every aspect of physiology. While GPCR signaling is essential …
regulate virtually every aspect of physiology. While GPCR signaling is essential …
Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases
Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage,
contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However …
contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However …