The hallmarks of cancer: a long non-coding RNA point of view
T Gutschner, S Diederichs - RNA biology, 2012 - Taylor & Francis
With the advent of next generation sequencing methods and progress in transcriptome
analysis, it became obvious that the human genome contains much more than just protein …
analysis, it became obvious that the human genome contains much more than just protein …
The functional role of long non-coding RNA in human carcinomas
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
Long noncoding RNA in cancer: wiring signaling circuitry
C Lin, L Yang - Trends in cell biology, 2018 - cell.com
Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the
human genome, may hold missing drivers of cancer and have gained attention recently as a …
human genome, may hold missing drivers of cancer and have gained attention recently as a …
Targeting long non-coding RNA to therapeutically upregulate gene expression
C Wahlestedt - Nature reviews Drug discovery, 2013 - nature.com
The majority of currently available drugs and tool compounds exhibit an inhibitory
mechanism of action and there is a relative lack of pharmaceutical agents that are capable …
mechanism of action and there is a relative lack of pharmaceutical agents that are capable …
Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets
The majority of the human genome is not translated into proteins but can be transcribed into
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …
The genetic signatures of noncoding RNAs
JS Mattick - PLoS genetics, 2009 - journals.plos.org
The majority of the genome in animals and plants is transcribed in a developmentally
regulated manner to produce large numbers of non–protein-coding RNAs (ncRNAs), whose …
regulated manner to produce large numbers of non–protein-coding RNAs (ncRNAs), whose …
Large non-coding RNAs: missing links in cancer?
Cellular homeostasis is achieved by the proper balance of regulatory networks that if
disrupted can lead to cellular transformation. These cell circuits are fine-tuned and …
disrupted can lead to cellular transformation. These cell circuits are fine-tuned and …
Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1)
Functional genomics studies have led to the discovery of a large amount of non-coding
RNAs from the human genome; among them are long non-coding RNAs (lncRNAs) …
RNAs from the human genome; among them are long non-coding RNAs (lncRNAs) …
[PDF][PDF] Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143
YL Tuo, XM Li, J Luo - Eur Rev Med Pharmacol Sci, 2015 - europeanreview.org
Art. 1.1475/ringraziamenti Page 1 Abstract. – OBJECTIVE: Long non coding RNA (LncRNA)
urothelial carcinoma-associated 1 (UCA1) is an oncogene in breast cancer. However, the …
urothelial carcinoma-associated 1 (UCA1) is an oncogene in breast cancer. However, the …
The emerging role of lncRNAs in the regulation of cancer stem cells
Background Tumors contain a functional subpopulation of cells that exhibit stem cell
properties. These cells, named cancer stem cells (CSCs), play significant roles in the …
properties. These cells, named cancer stem cells (CSCs), play significant roles in the …