This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

Caffeine is the most consumed pychostimulant in the world, and it is known to affect basic
and fundamental human processes such as sleep, arousal, cognition and learning and …

Tau pathology found in Alzheimer's disease (AD) is crucial in cognitive decline.
Epidemiologic evidences support that habitual caffeine intake prevents memory decline …

Major Depressive Disorder (MDD) is a growing disabling condition affecting around 280
million people worldwide. This complex entity is the result of the interplay between …

About 10 million new cases of dementia develop worldwide each year, of which up to 70%
are attributable to Alzheimer's disease (AD). In addition to the widely known symptoms of …

JCI - Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and
learning-dependent transcription Go to JCI Insight About Editors Consulting Editors For authors …

Background: Nonhuman studies suggest a protective effect of caffeine on cognition.
Although human literature remains less consistent, reviews suggest a possible favorable …

Natural caffeine is found in many plants, including coffee beans, cacao beans, and tea
leaves. Around the world, many beverages, including coffee, tea, energy drinks, and some …

The steady and dramatic increase in the incidence of Alzheimer's disease (AD) and the lack
of effective treatments have stimulated the search for strategies to prevent or delay its onset …

Although the diverse triggers of AD are still under debate, the hypothesis of the contribution
of cerebrovascular deficiencies has emerged in recent years. Cerebrovascular dysfunction …