Recurrent psychosocial stress poses a significant health challenge, prompting research into
mechanisms of successful adaptation. Physiological habituation, defined as decreased …

Over the past few years, the perceived level of psychological stress has risen dramatically
across the globe due to a combination of events including the long-lasting Covid-19 …

The human genome is largely noncoding, yet the field is still gras** to understand how
noncoding variants impact transcription and contribute to disease etiology. The massively …

Recent genetic studies have linked numerous loci to psychiatric disorders. However, the
biological pathways that connect these genetic associations to psychiatric disorders' specific …

Exposure to stressful life events is associated with a high risk of develo** psychiatric
disorders with a wide variety of symptoms. Cognitive symptoms in stress-related psychiatric …

Abstract The natural substitution Ala610Val in the porcine glucocorticoid receptor (GR
Ala610Val) leads to a profound compensatory downregulation of the hypothalamic–pituitary …

Early life stress (ELS) is a major risk factor for develo** psychiatric disorders, with
glucocorticoids (GCs) implicated in mediating its effects in sha** adult phenotypes. In this …

Since the turn of the 21st century, genome-wide association study (GWAS) have
successfully identified genetic signals associated with a myriad of common complex traits …

Background Alterations in the effects of glucocorticoids have been implicated in mediating
some of the negative health effects associated with chronic stress, including increased risk …

Glucocorticoids are important for proper organ maturation, and their levels are tightly
regulated during development. Here, we use human cerebral organoids and mice to study …