Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
FK Wiseman, T Al-Janabi, J Hardy… - Nature Reviews …, 2015 - nature.com
Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is
associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that …
associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
TREM2 is a receptor for β-amyloid that mediates microglial function
Mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to
increased Alzheimer's disease (AD) risk. Neurobiological functions of TREM2 and its …
increased Alzheimer's disease (AD) risk. Neurobiological functions of TREM2 and its …
Dementia in Down's syndrome
Down's syndrome is the most common genetic cause of learning difficulties, and individuals
with this condition represent the largest group of people with dementia under the age of 50 …
with this condition represent the largest group of people with dementia under the age of 50 …
Pathophysiological role of purines and pyrimidines in neurodevelopment: unveiling new pharmacological approaches to congenital brain diseases
M Fumagalli, D Lecca, MP Abbracchio… - Frontiers in …, 2017 - frontiersin.org
In recent years, a substantial body of evidence has emerged demonstrating that purine and
pyrimidine synthesis and metabolism play major roles in controlling embryonic and fetal …
pyrimidine synthesis and metabolism play major roles in controlling embryonic and fetal …
Roles of the miR-155 in neuroinflammation and neurological disorders: a potent biological and therapeutic target
SH Rastegar-Moghaddam… - Cellular and molecular …, 2023 - Springer
Neuroinflammation plays a crucial role in the development and progression of neurological
disorders. MicroRNA-155 (miR-155), a miR is known to play in inflammatory responses, is …
disorders. MicroRNA-155 (miR-155), a miR is known to play in inflammatory responses, is …
Contribution of the Presenilins in the cell biology, structure and function of γ-secretase
A Escamilla-Ayala, R Wouters, R Sannerud… - Seminars in cell & …, 2020 - Elsevier
Abstract γ-Secretase cleavage is essential for many biological processes and its
dysregulation is linked to disease, including cancer and Alzheimer's disease. Therefore …
dysregulation is linked to disease, including cancer and Alzheimer's disease. Therefore …
A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex
Recycling of internalized receptors from endosomal compartments is essential for the
receptors' cell-surface homeostasis. Sorting nexin 27 (SNX27) cooperates with the retromer …
receptors' cell-surface homeostasis. Sorting nexin 27 (SNX27) cooperates with the retromer …
Sorting nexins in protein homeostasis
SE Hanley, KF Cooper - Cells, 2020 - mdpi.com
Protein homeostasis is maintained by removing misfolded, damaged, or excess proteins and
damaged organelles from the cell by three major pathways; the ubiquitin-proteasome …
damaged organelles from the cell by three major pathways; the ubiquitin-proteasome …