ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters that is
preferentially localized along the rim region of rod and cone photoreceptor outer segment …

Viruses compete with each other for limited cellular resources, and some deliver defence
mechanisms that protect the host from competing genetic parasites. The phage …

Abscisic acid (ABA) is a phytohormone essential to the regulation of numerous aspects of
plant growth and development. The cellular level of ABA is critical to its signalling and is …

Production of high density lipoprotein (HDL) requires ATP-binding cassette transporter A1
(ABCA1) to drive phospholipid (PL) from the plasma membrane into extracellular …

The serine palmitoyltransferase (SPT) complex catalyzes the first and rate-limiting step in
sphingolipid biosynthesis in all eukaryotes. ORM/ORMDL proteins are negative regulators of …

Stargardt disease type 1 (STGD1) is the most common hereditary form of maculopathy and
remains untreatable. STGD1 is caused by biallelic variants in the ABCA4 gene, which …

Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to
peroxisome for β-oxidation, dysfunction of which usually causes the X-linked …

Bilirubin is mainly generated from the breakdown of heme when red blood cells reach the
end of their lifespan. Accumulation of bilirubin in human body usually leads to various …

Background ATP-binding cassette (ABC) transporter proteins constitute a plant gene
superfamily crucial for growth, development, and responses to environmental stresses …