Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

It has been suggested that highly social mammals, such as naked mole rats and humans,
are long-lived due to neoteny (the prolongation of youth). In both species, aging cannot …

The African naked mole-rat's (Heterocephalus glaber) social and subterranean lifestyle
generates a hypoxic niche. Under experimental conditions, naked mole-rats tolerate hours …

The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-
lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 …

Reconstructing the evolution of brain information-processing capacity is paramount for
understanding the rise of complex cognition. Comparative studies of brain evolution typically …

Abstract Naked mole rats (NMRs; Heterocephalus glaber) are the longest-living rodents
known, with a maximum lifespan of 30 years—5 times longer than expected on the basis of …

The brain requires over one-fifth of the total body oxygen demand for normal functioning. At
high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain …

Many vertebrates are challenged by either chronic or acute episodes of low oxygen
availability in their natural environments. Brain function is especially vulnerable to the effects …

Hypoxia is one of the strongest environmental drivers of cellular and physiological
adaptation. Although most mammals are largely intolerant of hypoxia, some specialized …

Hypoxia plays an important role in the development of many infectious, inflammatory, and
tumor diseases. The predisposition to such disorders is mostly provided by differences in …