Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

The P2X7 receptor is a non-selective cation channel activated by extracellular adenosine
triphosphate (ATP). Chronic activation of P2X7 underlies many health problems such as …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

Extracellular adenosine 5′ triphosphate (ATP) is a widespread cell-to-cell signaling
molecule in the brain, where it activates cell surface P2X and P2Y receptors. P2X receptors …

P2X 7 purinergic receptor engagement with extracellular ATP induces transmembrane
potassium and calcium flux resulting in assembly of the NLRP3 inflammasome in LPS …

P2X7 receptors (Rs) constitute a subclass of ATP-sensitive ionotropic receptors (P2X1-
P2X7). P2X7Rs have many distinguishing features, mostly based on their long intracellular …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

Purine nucleotides are well established as extracellular signaling molecules. P2X7
receptors (P2X7Rs) are members of the family of ionotropic ATP-gated receptors. Their …