Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …

There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …

Type 2 diabetes is caused by insulin resistance coupled with an inability to produce enough
insulin to control blood glucose, and thiazolidinediones (TZDs) are the only current …

Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which
precedes the development of type 2 diabetes mellitus and is thus the driving force behind …

Brown adipose tissue dissipates energy through heat and functions as a defense against
cold and obesity. PPARγ ligands have been shown to induce the browning of white …

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor
superfamily and they are essential regulators of cell differentiation, tissue development, and …

Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects
genes controlling vital processes. Among them, the peroxisome proliferator-activated …

The pathophysiology of sepsis and its accompanying systemic inflammatory response
syndrome (SIRS) and the events that lead to multiorgan failure and death are poorly …