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[HTML][HTML] A comprehensive review on pyrazoline based heterocyclic hybrids as potent anticancer agents
Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
[HTML][HTML] Pyrazoline hybrids as promising anticancer agents: An up-to-date overview
Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have
attracted significant attention from organic and medicinal chemists due to their potent …
attracted significant attention from organic and medicinal chemists due to their potent …
Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes
Thiazole derivatives remains honored heterocycles in the field of medicinal chemistry. This
scaffold has been proven as a universal motif that is present in numerous pharmacologically …
scaffold has been proven as a universal motif that is present in numerous pharmacologically …
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
[HTML][HTML] 1, 3, 4-Oxadiazole-containing hybrids as potential anticancer agents: Recent developments, mechanism of action and structure-activity relationships
Chemotherapy is an important therapeutic approach for the treatment of cancer. Currently,
many anticancer drugs are available in the market that plays an important role in cancer …
many anticancer drugs are available in the market that plays an important role in cancer …
Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors
Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The
treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of …
treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of …
Development in the synthesis of bioactive thiazole-based heterocyclic hybrids utilizing phenacyl bromide
Heterocyclic hybrid frameworks represent a burgeoning domain within the realms of drug
discovery and medicinal chemistry, attracting considerable attention in recent years …
discovery and medicinal chemistry, attracting considerable attention in recent years …
New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti …
Two new series of pyrazolyl-thiazolidinone/thiazole derivatives 16a–b and 18a–j were
synthesised, merging the scaffolds of celecoxib and dasatinib. Compounds 16a, 16b and 18f …
synthesised, merging the scaffolds of celecoxib and dasatinib. Compounds 16a, 16b and 18f …
A comprehensive review on thiazole based conjugates as anti-cancer agents
Over the past few decades, a significant number of anticancer drugs have been developed,
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …
[HTML][HTML] New Thiazolyl-Pyrazoline derivatives as potential dual EGFR/HER2 inhibitors: design, synthesis, anticancer activity evaluation and in silico study
A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b)
have been designed and synthesized through the combination of thiazole and pyrazoline …
have been designed and synthesized through the combination of thiazole and pyrazoline …