Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors
L Zhang, Y Liu, H Huang, H **e, B Zhang, W **a… - Advanced drug delivery …, 2022 - Elsevier
Malignant brain tumors, a heterogeneous group of primary and metastatic neoplasms in the
central nervous system (CNS), are notorious for their highly invasive and devastating …
central nervous system (CNS), are notorious for their highly invasive and devastating …
[HTML][HTML] An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines
The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …
Evolution of drug delivery systems: From 1950 to 2020 and beyond
H Park, A Otte, K Park - Journal of Controlled Release, 2022 - Elsevier
Modern drug delivery technology began in 1952 with the advent of the Spansule® sustained-
release capsule technology, which can deliver a drug for 12 h after oral administration …
release capsule technology, which can deliver a drug for 12 h after oral administration …
[HTML][HTML] Organ-specific endothelial cell heterogenicity and its impact on regenerative medicine and biomedical engineering applications
Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …
Vascularizing the brain in vitro
The brain is arguably the most fascinating and complex organ in the human body.
Recreating the brain in vitro is an ambition restricted by our limited understanding of its …
Recreating the brain in vitro is an ambition restricted by our limited understanding of its …
[HTML][HTML] Models to study basic and applied aspects of lysosomal storage disorders
The lack of available treatments and fatal outcome in most lysosomal storage disorders
(LSDs) have spurred research on pathological mechanisms and novel therapies in recent …
(LSDs) have spurred research on pathological mechanisms and novel therapies in recent …
Performance of nanoparticles for biomedical applications: The in vitro/in vivo discrepancy
S Berger, M Berger, C Bantz, M Maskos… - Biophysics Reviews, 2022 - pubs.aip.org
Nanomedicine has a great potential to revolutionize the therapeutic landscape. However, up-
to-date results obtained from in vitro experiments predict the in vivo performance of …
to-date results obtained from in vitro experiments predict the in vivo performance of …
[HTML][HTML] A new frontier in neuropharmacology: recent progress in natural products research for blood–brain barrier crossing
UV Isabel, ARM Belén, GB Elena - Current Research in Biotechnology, 2024 - Elsevier
Neuropharmacology faces challenges due to the intricate nervous system, diverse
neurological disorders, and existence of the blood–brain barrier (BBB), which hinder the …
neurological disorders, and existence of the blood–brain barrier (BBB), which hinder the …
Advances in hydrogel-based microfluidic blood–brain-barrier models in oncology research
The intrinsic architecture and complexity of the brain restricts the capacity of therapeutic
molecules to reach their potential targets, thereby limiting therapeutic possibilities …
molecules to reach their potential targets, thereby limiting therapeutic possibilities …
Subcellular analysis of blood-brain barrier function by micro-impalement of vessels in acute brain slices
AS Hanafy, P Steinlein, J Pitsch, MH Silva… - Nature …, 2023 - nature.com
The blood-brain barrier (BBB) is a tightly and actively regulated vascular barrier. Answering
fundamental biological and translational questions about the BBB with currently available …
fundamental biological and translational questions about the BBB with currently available …